What is Kenig's Disease?

Description of the disease

Kenig's disease, also known as Perthes disease, is a rare genetic condition that leads to the development of painful tumors in the bones. It usually begins in adolescence and can lead to restricted movement and bone deformities.

Classification

• Type 1: Beneficial tumor disease
• Type 2: Congenital disease dysplasia
• Type 3: Multifocal chronic dysplasia

Symptoms

• Bone pain
• Restricted movement
• Bone deformities

Causes

Kenig's disease is caused by a mutation in the NOD2 gene, which controls the body's inflammatory response. This leads to excessive activation of osteoclasts, resulting in bone tissue destruction.

Diagnosis

Diagnosis of Kenig's disease usually involves X-rays, computed tomography, or magnetic resonance imaging to assess the condition of the bones.

Treatment

Treatment of Kenig's disease often involves the use of anti-inflammatory drugs, bisphosphonates, or surgical intervention for reconstruction or stabilization of affected bones.

Prevention

Since Kenig's disease is a genetic condition, prevention involves genetic counseling and screening of relatives to identify the risk of developing the disease.

Doctor

Treatment and monitoring of patients with Kenig's disease is conducted by a rheumatologist or orthopedic surgeon.