The medicinal product exhibits a calming effect on the central nervous system and also has a moderate reflex vasodilating (coronary) effect by reflex irritation of sensitive nerve ("cold") receptors of the oral mucosa. Stimulation of the receptors is accompanied by the release of endorphins, enkephalins, dynorphins, and other peptides, histamine, kinins, which play an important role in reducing pain sensitivity, normalizing vascular permeability, and regulating other important mechanisms of cardiovascular and nervous system function.
Pharmacokinetics:
When administered sublingually, Corvalment® is absorbed from the mucous membrane of the oral cavity. The therapeutic effect occurs approximately 5 minutes after administration.
After absorption, it undergoes biotransformation in the liver and is excreted in the urine as glucuronides.
Indications: Mild angina attacks; Motion sickness; Hysteria; Neurosis; Headaches associated with the use of nitrates.
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Use in cases of fractures, contusions, rheumatism, inflammation of the spinal nerves (radiculitis), blood clots, gynecology, tumors, eczema, hemorrhoids, inflammation of the urinary bladder, baldness, inflammations, stomach ulcer, heartburn, brash, and high blood pressure.
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Coldrex HotRem is a combination drug prescribed for acute respiratory infections, established flu, and fever of an unknown nature. This medicine is often used in medical practice. Coldrex HotRem reviews are mostly positive. Among the advantages are ease of use, a large amount of vitamin C, good taste. Available with various flavors.
Milistan multisymptomic is a combined drug that includes paracetamol, cetirizine hydrochloride, chlorpheniramine maleate, and dextromethorphan hydrobromide. Given the antitussive, antihistamine, analgesic, antipyretic, anti-inflammatory effect of the components of the drug milistan multi-symptom, it is recommended to use it for acute respiratory viral infections, in particular for acute rhinitis, pharyngitis and tracheobronchitis, as symptomatic therapy. The drug allows you to cope with an irritating dry cough, lacrimation, runny nose, nasal congestion, as well as with such common symptoms as headache, muscle and joint pain, fever, allergic manifestations of the disease.