The medicinal product exhibits a calming effect on the central nervous system and also has a moderate reflex vasodilating (coronary) effect by reflex irritation of sensitive nerve ("cold") receptors of the oral mucosa. Stimulation of the receptors is accompanied by the release of endorphins, enkephalins, dynorphins, and other peptides, histamine, kinins, which play an important role in reducing pain sensitivity, normalizing vascular permeability, and regulating other important mechanisms of cardiovascular and nervous system function.
Pharmacokinetics:
When administered sublingually, Corvalment® is absorbed from the mucous membrane of the oral cavity. The therapeutic effect occurs approximately 5 minutes after administration.
After absorption, it undergoes biotransformation in the liver and is excreted in the urine as glucuronides.
Indications: Mild angina attacks; Motion sickness; Hysteria; Neurosis; Headaches associated with the use of nitrates.
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Diseases associated with hyperuricemia (treatment and prevention): gout (primary and secondary), urolithiasis (with urate formation).
Hyperuricemia (primary and secondary) occurring in diseases accompanied by increased breakdown of nucleoproteins and elevated uric acid levels in the blood, including various hematological malignancies (acute leukemia, chronic myeloid leukemia, lymphosarcoma, etc.), during cytostatic and radiation therapy for tumors (including in children), psoriasis, extensive traumatic injuries, due to enzymatic disorders (Lesch-Nyhan syndrome), as well as during massive glucocorticoid therapy, where the intensive tissue breakdown significantly increases the amount of purines in the blood.
Uric acid nephropathy with impaired kidney function (renal insufficiency).
Recurrent mixed oxalate-calcium kidney stones (with uricosuria).
Infectious and inflammatory diseases (ARVI, flu), accompanied by: